Buy MOTSc Peptide – Premium 99% Research Grade Powder | AMP

Description

Buy MOTSc peptide for in vitro research from American Made Peptides — the trusted USA source for premium mitochondrial-derived peptide research compounds. We supply MOTSc peptide as a lyophilized powder of ≥99% purity, independently verified by third-party HPLC analysis.

Every vial is manufactured in the USA and ships with a Certificate of Analysis confirming peptide identity and purity. For research use only.
Not for human consumption.

Where to Buy MOTSc Peptide – Research Overview

MOTSc (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial 12S ribosomal RNA gene.

Discovered in 2015, MOTSc represents a novel class of bioactive peptides originating from the mitochondrial genome rather than the nuclear genome — making it uniquely relevant to mitochondrial biology and aging research.

MOTSc consists of 16 amino acids and has been studied for its role in metabolic regulation, cellular stress responses, and mitochondrial communication pathways.

Research Applications

Mitochondrial Biology Research

MOTSc is one of a small family of mitochondrial-derived peptides that act as signaling molecules in cellular metabolism.

Researchers use MOTSc to study mitochondrial-nuclear communication, retrograde signaling pathways, and how mitochondrial peptides regulate
nuclear gene expression related to metabolism and stress response.

AMPK Pathway Research

MOTSc has been studied for its ability to activate AMP-activated protein kinase (AMPK), a master regulator of cellular energy homeostasis.

AMPK activation by MOTSc has been investigated in the context of glucose uptake, fatty acid oxidation, and mitochondrial biogenesis in skeletal muscle and hepatocyte cell models.

Cellular Stress and Hormesis Research

MOTSc expression is upregulated in response to cellular stress conditions including reactive oxygen species (ROS) accumulation and metabolic stress.

This makes MOTSc a valuable tool compound for studying hormetic stress response pathways, mitohormesis, and cellular resilience mechanisms in aging research models.

Longevity and Aging Research

MOTSc has been studied in the context of healthspan and aging biology. Research programs have examined its effects on insulin sensitivity, inflammatory pathway modulation, and age-related metabolic decline mechanisms in preclinical models.

View published MOTSc research on
PubMed.

Why Buy MOTSc Peptide From American Made Peptides?

Researchers who buy MOTSc peptide from AMP receive a full third-party COA with every order, confirming ≥99% purity by HPLC chromatography.

USA Manufactured — no overseas sourcing or repackaging.

Third-Party Tested — independently verified by a US-based laboratory.

HPLC Verified — purity confirmed at ≥98% on every batch.

Lyophilized for Stability — powder format ensures maximum shelf life under proper storage conditions.

Learn more on our Lab Testing & COA Hub.

Technical Specifications

Origin	Mitochondrial 12S rRNA gene
Amino Acids	16
Molecular Weight	~2174 g/mol
Primary Target	AMPK activation pathway
Purity	≥99% (HPLC verified)
Form	Lyophilized powder
Appearance	White to off-white powder
Storage	-20°C, away from light and moisture
Reconstitution	Bacteriostatic water recommended
Shelf Life	24 months lyophilized / 30 days reconstituted at 4°C

Storage and Handling

Store lyophilized MOTSc at -20°C in a dry environment, protected from direct light and humidity.

Once reconstituted with bacteriostatic water, store at 4°C and use within 30 days. Do not refreeze reconstituted peptide.

MOTSc is particularly sensitive to oxidative degradation. Minimize exposure to air during reconstitution and handling.

Certificate of Analysis

When you buy MOTSc peptide from American Made Peptides, every batch ships with a downloadable Certificate of Analysis.

Visit our Lab Testing & COA Hub for full testing methodology details.

Frequently Asked Questions

Why do researchers buy MOTSc peptide for lab studies?

Researchers buy MOTSc peptide to study mitochondrial-nuclear communication, AMPK pathway activation, cellular stress responses, and aging-related metabolic mechanisms. As a mitochondrial-derived peptide, MOTSc is uniquely positioned at the intersection of mitochondrial biology and metabolic research.

What makes MOTSc different from other research peptides?

MOTSc is one of the very few peptides encoded by the mitochondrial genome rather than the nuclear genome. This origin makes it a fundamentally unique tool compound for studying mitochondrial signaling and retrograde communication with the nucleus.

What purity level does your MOTSc meet?

All AMP MOTSc is independently verified at ≥99% purity by third-party HPLC analysis. A full COA is available for download.

How should lyophilized MOTSc be stored?

Store at -20°C in a dry, light-protected environment away from oxidative conditions. Once reconstituted, store at 4°C and use within 30 days. Do not refreeze.

What payment methods do you accept?

We accept Bitcoin (BTC), Ethereum (ETH), and USDC. Credit card processing coming soon. All crypto payments processed instantly.

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⚠️ RESEARCH USE ONLY: This product is sold strictly for in vitro research and laboratory use only. Not for human or animal consumption. Not evaluated by the FDA. Must be 18+ to purchase. All sales are final.